Any arrangement in the back seat is safe, provided that each child seat can be correctly installed and used in the seating position you select.
Some advocates actually prefer to try a front facing toddler seat in the center and a rear facing infant seat outside first, because the rear-facing infant seat may provide more side impact protection. Really, any way you can get them into a rear seat with good installations will be fine, even if you put them both on the outside.
Some things to consider in new vehicles include side curtain airbags in all rows of seating. Also, if you do choose to have two seats adjacent to each other, a few models do have three separate sets of LATCH anchors in a row. This is not typical, however, and most vehicles do not have the capability to allow two adjacent child restraints to be installed with LATCH at the same time.
The Honda Pilot is a safe choice, however, the only sure way to know if your seats will fit side-by-side is to try them in person. Unless you find someone with the exact same child seats and the exact same year and trim level vehicle, it may be impossible to say for sure.
One vehicle I KNOW should work is an 8-passenger Toyota Sienna CE or LE. The 2nd row center seat is ideal for child seat as it has LATCH and can be moved forward halfway between the front seats for easier access. The remaining seats in the second row also have LATCH and should have plenty of room for most child restraints, too.